Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5603578 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Wang Yidong Y Wu Bingruo B Lu Pengfei P Zhang Donghong D Wu Brian B Varshney Shweta S Del Monte-Nieto Gonzalo G Zhuang Zhenwu Z Charafeddine Rabab R Kramer Adam H AH Sibinga Nicolas E NE Frangogiannis Nikolaos G NG Kitsis Richard N RN Adams Ralf H RH Alitalo Kari K Sharp David J DJ Harvey Richard P RP Stanley Pamela P Zhou Bin B
Nature communications 20170918 1
Coronary artery anomalies may cause life-threatening cardiac complications; however, developmental mechanisms underpinning coronary artery formation remain ill-defined. Here we identify an angiogenic cell population for coronary artery formation in mice. Regulated by a DLL4/NOTCH1/VEGFA/VEGFR2 signaling axis, these angiogenic cells generate mature coronary arteries. The NOTCH modulator POFUT1 critically regulates this signaling axis. POFUT1 inactivation disrupts signaling events and results in e ...[more]