Continuous Monitoring via Tethered Electroencephalography of Spontaneous Recurrent Seizures in Mice.

ABSTRACT: We describe here a simple, cost-effective apparatus for continuous tethered electroencephalographic (EEG) monitoring of spontaneous recurrent seizures in mice. We used a small, low torque slip ring as an EEG commutator, mounted the slip ring onto a standard mouse cage and connected rotary wires of the slip ring directly to animal's implanted headset. Modifications were made in the cage to allow for a convenient installation of the slip ring and accommodation of animal ambient activity. We tested the apparatus for hippocampal EEG recordings in adult C57 black mice. Spontaneous recurrent seizures were induced using extended hippocampal kindling (≥95 daily stimulation). Control animals underwent similar hippocampal electrode implantations but no stimulations were given. Combined EEG and webca

SUBMITTER: Bin NR 

PROVIDER: S-EPMC5603658 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature