Ontology highlight
ABSTRACT:
SUBMITTER: Rao TD
PROVIDER: S-EPMC5603915 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Rao Thapi Dharma TD Fernández-Tejada Alberto A Axelrod Abram A Rosales Nestor N Yan Xiujun X Thapi Sahityasri S Wang Amy A Park Kay J KJ Nemieboka Brandon B Xiang Jingyi J Lewis Jason S JS Olvera Narciso N Levine Douglas A DA Danishefsky Samuel J SJ Spriggs David R DR
ACS chemical biology 20170628 8
Expression of the retained C-terminal extracellular portion of the ovarian cancer glycoprotein MUC16 induces transformation and tumor growth. However, the mechanisms of MUC16 oncogenesis related to glycosylation are not clearly defined. We establish that MUC16 oncogenic effects are mediated through MGAT5-dependent N-glycosylation of two specific asparagine sites within its 58 amino acid ectodomain. Oncogenic signaling from the C-terminal portion of MUC16 requires the presence of Galectin-3 and g ...[more]