Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC5603960 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Chen Wanping W Chen Runfa R Liu Qingpei Q He Yi Y He Kun K Ding Xiaoli X Kang Lijing L Guo Xiaoxiao X Xie Nana N Zhou Youxiang Y Lu Yuanyuan Y Cox Russell J RJ Molnár István I Li Mu M Shao Yanchun Y Chen Fusheng F
Chemical science 20170424 7
<i>Monascus</i> azaphilone pigments (MonAzPs) are very widely used as food colorants, but their biosynthetic pathway has remained poorly characterized for more than half a century. In this study, the individual steps of MonAzPs biosynthesis in <i>Monascus ruber</i> M7 were elucidated by a combination of targeted gene knockouts, heterologous gene expression, and <i>in vitro</i> chemical and enzymatic reactions. This study describes the first rational engineering of MonAzPs biosynthesis and provid ...[more]