Ontology highlight
ABSTRACT:
SUBMITTER: Zhang XS
PROVIDER: S-EPMC5604040 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Zhang Xiao-Shuai XS Wang Tao T Lin Xian-Wu XW Denlinger David L DL Xu Wei-Hua WH
Proceedings of the National Academy of Sciences of the United States of America 20170828 37
Reactive oxygen species (ROS) are well-known accelerants of aging, but, paradoxically, we show that physiological levels of ROS extend life span in pupae of the moth <i>Helicoverpa armigera</i>, resulting in the dormant state of diapause. This developmental switch appears to operate through a variant of the conventional insulin-signaling pathway, as evidenced by the facts that Akt, p-Akt, and PRMT1 are elevated by ROS, but not insulin, and that high levels of p-Akt fail to phosphorylate FoxO thr ...[more]