Ontology highlight
ABSTRACT:
SUBMITTER: Thayyil S
PROVIDER: S-EPMC5604260 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Thayyil Sudhin S Oliveira Vania V Lally Peter J PJ Swamy Ravi R Bassett Paul P Chandrasekaran Mani M Mondkar Jayashree J Mangalabharathi Sundaram S Benkappa Naveen N Seeralar Arasar A Shahidullah Mohammod M Montaldo Paolo P Herberg Jethro J Manerkar Swati S Kumaraswami Kumutha K Kamalaratnam Chinnathambi C Prakash Vinayagam V Chandramohan Rema R Bandya Prathik P Mannan Mohammod Abdul MA Rodrigo Ranmali R Nair Mohandas M Ramji Siddarth S Shankaran Seetha S
Trials 20170918 1
<h4>Background</h4>Therapeutic hypothermia reduces death and disability after moderate or severe neonatal encephalopathy in high-income countries and is used as standard therapy in these settings. However, the safety and efficacy of cooling therapy in low- and middle-income countries (LMICs), where 99% of the disease burden occurs, remains unclear. We will examine whether whole body cooling reduces death or neurodisability at 18-22 months after neonatal encephalopathy, in LMICs.<h4>Methods</h4>W ...[more]