Whole blood gene expression and white matter Hyperintensities.
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ABSTRACT:
SUBMITTER: Lin H
PROVIDER: S-EPMC5604498 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Whole blood gene expression and white matter Hyperintensities.
Lin Honghuang H Satizabal Claudia C Xie Zhijun Z Yang Qiong Q Huan Tianxiao T Joehanes Roby R Wen Chengping C Munson Peter J PJ Beiser Alexa A Levy Daniel D Seshadri Sudha S
Molecular neurodegeneration 20170918 1
<h4>Background</h4>White matter hyperintensities (WMH) are an important biomarker of cumulative vascular brain injury and have been associated with cognitive decline and an increased risk of dementia, stroke, depression, and gait impairments. The pathogenesis of white matter lesions however, remains uncertain. The characterization of gene expression profiles associated with WMH might help uncover molecular mechanisms underlying WMH.<h4>Methods</h4>We performed a transcriptome-wide association st ...[more]
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