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Percutaneous intratumoral injection of gemcitabine plus cisplatin mixed with fibrin glue for advanced pancreatic carcinoma: Case Report.


ABSTRACT:

Rationale

The aim of this study was to determine the effectiveness of intratumoral injection of chemotherapeutics in improving the quality of life and survival of patients with pancreatic carcinoma.

Patient concerns

We present a case series of 5 patients with unresectable pancreatic adenocarcinoma.

Diagnoses

Patients diagnosed with unresectable poorly differentiated pancreatic ductal adenocarcinoma by intraoperative frozen biopsyor percutaneous biopsy.

Interventions

Five patients with unresectable pancreatic adenocarcinoma received a computed tomography-guided percutaneous intratumoral injection of gemcitabine plus cisplatin mixed with fibrin glue.

Outcomes

Mean overall survival was 16.2?±?3.7 months. Local control rates were 100% and 80% at postoperative 3 and 6 months, respectively. Mean Visual Analogue Scale pain score decreased from 7.2?±?.84 preoperatively to 2?±?1.22 at postoperative 4 weeks. There were no complications associated with the procedure.

Lessons

Percutaneous intratumoral injection of gemcitabine plus cisplatin mixed with fibrin glue for advanced pancreatic may be safe and effective.

SUBMITTER: Yang B 

PROVIDER: S-EPMC5604654 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Publications

Percutaneous intratumoral injection of gemcitabine plus cisplatin mixed with fibrin glue for advanced pancreatic carcinoma: Case Report.

Yang Biao B   He Jian-Ping JP   Yuan Min-Lan ML   Li Wei W   Jiao He H   You Xin X   Liu Xing-Rong XR   Zhao Jian J   Li Chun-Lin CL   Fu Xiao-Bo XB   Liao Zheng-Yin ZY   Yi Cheng C  

Medicine 20170901 37


<h4>Rationale</h4>The aim of this study was to determine the effectiveness of intratumoral injection of chemotherapeutics in improving the quality of life and survival of patients with pancreatic carcinoma.<h4>Patient concerns</h4>We present a case series of 5 patients with unresectable pancreatic adenocarcinoma.<h4>Diagnoses</h4>Patients diagnosed with unresectable poorly differentiated pancreatic ductal adenocarcinoma by intraoperative frozen biopsyor percutaneous biopsy.<h4>Interventions</h4>  ...[more]

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