Ontology highlight
ABSTRACT: Rationale
The aim of this study was to determine the effectiveness of intratumoral injection of chemotherapeutics in improving the quality of life and survival of patients with pancreatic carcinoma.Patient concerns
We present a case series of 5 patients with unresectable pancreatic adenocarcinoma.Diagnoses
Patients diagnosed with unresectable poorly differentiated pancreatic ductal adenocarcinoma by intraoperative frozen biopsyor percutaneous biopsy.Interventions
Five patients with unresectable pancreatic adenocarcinoma received a computed tomography-guided percutaneous intratumoral injection of gemcitabine plus cisplatin mixed with fibrin glue.Outcomes
Mean overall survival was 16.2?±?3.7 months. Local control rates were 100% and 80% at postoperative 3 and 6 months, respectively. Mean Visual Analogue Scale pain score decreased from 7.2?±?.84 preoperatively to 2?±?1.22 at postoperative 4 weeks. There were no complications associated with the procedure.Lessons
Percutaneous intratumoral injection of gemcitabine plus cisplatin mixed with fibrin glue for advanced pancreatic may be safe and effective.
SUBMITTER: Yang B
PROVIDER: S-EPMC5604654 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Yang Biao B He Jian-Ping JP Yuan Min-Lan ML Li Wei W Jiao He H You Xin X Liu Xing-Rong XR Zhao Jian J Li Chun-Lin CL Fu Xiao-Bo XB Liao Zheng-Yin ZY Yi Cheng C
Medicine 20170901 37
<h4>Rationale</h4>The aim of this study was to determine the effectiveness of intratumoral injection of chemotherapeutics in improving the quality of life and survival of patients with pancreatic carcinoma.<h4>Patient concerns</h4>We present a case series of 5 patients with unresectable pancreatic adenocarcinoma.<h4>Diagnoses</h4>Patients diagnosed with unresectable poorly differentiated pancreatic ductal adenocarcinoma by intraoperative frozen biopsyor percutaneous biopsy.<h4>Interventions</h4> ...[more]