Ontology highlight
ABSTRACT:
SUBMITTER: Owen SA
PROVIDER: S-EPMC5604731 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Owen S A SA Hider S L SL Martin P P Bruce I N IN Barton A A Thomson W W
The pharmacogenomics journal 20120327 3
We investigated the effect of single-nucleotide polymorphisms (SNPs) spanning 10 methotrexate (MTX) pathway genes, namely AMPD1, ATIC, DHFR, FPGS, GGH, ITPA, MTHFD1, SHMT1, SLC19A1 (RFC) and TYMS on the outcome of MTX treatment in a UK rheumatoid arthritis (RA) patient cohort. Tagging SNPs were selected and genotyping was performed in 309 patients with predefined outcomes to MTX treatment. Of the 129 SNPs tested, 11 associations were detected with efficacy (P-trend 0.05) including four SNPs in ...[more]