Ontology highlight
ABSTRACT:
SUBMITTER: Pei W
PROVIDER: S-EPMC5605149 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Pei Wuhong W Tanaka Katsuya K Huang Sunny C SC Xu Lisha L Liu Baoying B Sinclair Jason J Idol Jennifer J Varshney Gaurav K GK Huang Haigen H Lin Shuo S Nussenblatt Robert B RB Mori Ryoichi R Burgess Shawn M SM
NPJ Regenerative medicine 20161027
After injury, zebrafish can restore many tissues that do not regenerate well in mammals, making it a useful vertebrate model for studying regenerative biology. We performed a systematic screen to identify genes essential for hair cell regeneration in zebrafish, and found that the heat shock protein Hspd1 (Hsp60) has a critical role in the regeneration of hair cells and amputated caudal fins. We showed HSP60-injected extracellularly promoted cell proliferation and regeneration in both hair cells ...[more]