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Applied Cancer Immunogenomics: Leveraging Neoantigen Discovery in Glioblastoma.

ABSTRACT: Glioblastoma (GBM) remains a significant cause of cancer-related mortality in pediatric and adult patients with limited treatment options. Immunotherapy represents a promising new therapeutic approach in many solid and hematologic malignancies, including GBM, although only a subset of patients responds clinically. Thus, current efforts are focused on identifying patients most likely to benefit from immune-based therapies. The cancer immunogenomics approach identifies candidate neoantigens from genomics information and represents a potentially exciting new space in precision neuro-oncology. In this review, we discuss the role of neoantigens in GBM both as predictive biomarkers and as targets of immunotherapy.

SUBMITTER: Johanns TM

PROVIDER: S-EPMC5605294 | biostudies-literature | 2017 Mar/Apr

REPOSITORIES: biostudies-literature

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Applied Cancer Immunogenomics: Leveraging Neoantigen Discovery in Glioblastoma.

Johanns Tanner M TM Dunn Gavin P GP

Cancer journal (Sudbury, Mass.) 20170301 2

Glioblastoma (GBM) remains a significant cause of cancer-related mortality in pediatric and adult patients with limited treatment options. Immunotherapy represents a promising new therapeutic approach in many solid and hematologic malignancies, including GBM, although only a subset of patients responds clinically. Thus, current efforts are focused on identifying patients most likely to benefit from immune-based therapies. The cancer immunogenomics approach identifies candidate neoantigens from g ...[more]

PMID: 28410300

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