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IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues.


ABSTRACT: IL-15 is an essential cytokine known to promote T cell survival and activate the effector function of memory phenotype CD8 T cells. Blocking IL-15 signals also significantly impacts tissue-specific effector and memory CD8 T cell formation. In this study, we demonstrate that IL-15 influences the generation of memory CD8 T cells by first promoting their accumulation into mucosal tissues and second by sustaining expression of Bcl-6 and T-bet. We show that the mechanism for this recruitment is largely dependent on mammalian target of rapamycin and its subsequent inactivation of FoxO1. Last, we show that IL-15 complexes delivered locally to mucosal tissues without reinfection is an effective strategy to enhance establishment of tissue resident memory CD8 T cells within mucosal tissues. This study provides mechanistic insight into how IL-15 controls the generation of memory CD8 T cells and influences their trafficking and ability to take up residence within peripheral tissues.

SUBMITTER: Sowell RT 

PROVIDER: S-EPMC5605445 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues.

Sowell Ryan T RT   Goldufsky Josef W JW   Rogozinska Magdalena M   Quiles Zurisaday Z   Cao Yanxia Y   Castillo Eliseo F EF   Finnegan Alison A   Marzo Amanda L AL  

Journal of immunology (Baltimore, Md. : 1950) 20170816 7


IL-15 is an essential cytokine known to promote T cell survival and activate the effector function of memory phenotype CD8 T cells. Blocking IL-15 signals also significantly impacts tissue-specific effector and memory CD8 T cell formation. In this study, we demonstrate that IL-15 influences the generation of memory CD8 T cells by first promoting their accumulation into mucosal tissues and second by sustaining expression of Bcl-6 and T-bet. We show that the mechanism for this recruitment is large  ...[more]

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