Ontology highlight
ABSTRACT:
SUBMITTER: Epstein Y
PROVIDER: S-EPMC5605507 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Epstein Yehonatan Y Perry Noam N Volin Marina M Zohar-Fux Maayan M Braun Rachel R Porat-Kuperstein Lilach L Toledano Hila H
Nature communications 20170919 1
Ageing is characterized by a decline in stem cell functionality leading to dampened tissue regeneration. While the expression of microRNAs across multiple species is markedly altered with age, the mechanism by which they govern stem cell-sustained tissue regeneration is unknown. We report that in the Drosophila testis, the conserved miR-9a is expressed in germline stem cells and its levels are significantly elevated during ageing. Transcriptome and functional analyses show that miR-9a directly r ...[more]