Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90.
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ABSTRACT:
SUBMITTER: Zhang G
PROVIDER: S-EPMC5605540 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90.
Zhang Guohua G Liu Zhelong Z Ding Hui H Zhou Yong Y Doan Hoang Anh HA Sin Ka Wai Thomas KWT Zhu Zhiren J ZJ Flores Rene R Wen Yefei Y Gong Xing X Liu Qingyun Q Li Yi-Ping YP
Nature communications 20170919 1
Cachexia, characterized by muscle wasting, is a major contributor to cancer-related mortality. However, the key cachexins that mediate cancer-induced muscle wasting remain elusive. Here, we show that tumor-released extracellular Hsp70 and Hsp90 are responsible for tumor's capacity to induce muscle wasting. We detected high-level constitutive release of Hsp70 and Hsp90 associated with extracellular vesicles (EVs) from diverse cachexia-inducing tumor cells, resulting in elevated serum levels in mi ...[more]
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2020-07-06 | PXD004865 | Pride
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