Ontology highlight
ABSTRACT:
SUBMITTER: Dushyanthen S
PROVIDER: S-EPMC5605577 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Dushyanthen Sathana S Teo Zhi Ling ZL Caramia Franco F Savas Peter P Mintoff Christopher P CP Virassamy Balaji B Henderson Melissa A MA Luen Stephen J SJ Mansour Mariam M Kershaw Michael H MH Trapani Joseph A JA Neeson Paul J PJ Salgado Roberto R McArthur Grant A GA Balko Justin M JM Beavis Paul A PA Darcy Phillip K PK Loi Sherene S
Nature communications 20170919 1
The presence of tumor-infiltrating lymphocytes in triple-negative breast cancers is correlated with improved outcomes. Ras/MAPK pathway activation is associated with significantly lower levels of tumor-infiltrating lymphocytes in triple-negative breast cancers and while MEK inhibition can promote recruitment of tumor-infiltrating lymphocytes to the tumor, here we show that MEK inhibition adversely affects early onset T-cell effector function. We show that α-4-1BB and α-OX-40 T-cell agonist antib ...[more]