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The role of receptor binding specificity in interspecies transmission of influenza viruses.


ABSTRACT: Influenza A virus infection begins with the binding of the hemagglutinin (HA) glycoprotein to sialic acid-containing receptors on the surface of the target cell. Avian influenza viruses, including avian H5N1, H7, and H9N2 viruses, can occasionally cross the species barrier and infect humans; however, these viruses do not spread efficiently from person to person, perhaps, partly, owing to differences in the receptor-binding specificities of human and avian influenza viruses. The HAs of avian influenza viruses must adapt to receptors in humans to acquire efficient human-to-human transmissibility. In this review, we discuss the receptor binding specificity of influenza A viruses and its role in interspecies transmission.

SUBMITTER: Imai M 

PROVIDER: S-EPMC5605752 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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The role of receptor binding specificity in interspecies transmission of influenza viruses.

Imai Masaki M   Kawaoka Yoshihiro Y  

Current opinion in virology 20120324 2


Influenza A virus infection begins with the binding of the hemagglutinin (HA) glycoprotein to sialic acid-containing receptors on the surface of the target cell. Avian influenza viruses, including avian H5N1, H7, and H9N2 viruses, can occasionally cross the species barrier and infect humans; however, these viruses do not spread efficiently from person to person, perhaps, partly, owing to differences in the receptor-binding specificities of human and avian influenza viruses. The HAs of avian infl  ...[more]

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