Ontology highlight
ABSTRACT:
SUBMITTER: Sadler JE
PROVIDER: S-EPMC5606001 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
The discovery of a disintegrin-like and metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS13) revolutionized our approach to thrombotic thrombocytopenic purpura (TTP). Inherited or acquired ADAMTS13 deficiency allows the unrestrained growth of microthrombi that are composed of von Willebrand factor and platelets, which account for the thrombocytopenia, hemolytic anemia, schistocytes, and tissue injury that characterize TTP. Most patients with acquired TTP respond to a combinat ...[more]