Ontology highlight
ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC5606162 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Zhou Jia J Chan Jany J Lambelé Marie M Yusufzai Timur T Stumpff Jason J Opresko Patricia L PL Thali Markus M Wallace Susan S SS
Cell reports 20170801 9
Oxidative damage to telomere DNA compromises telomere integrity. We recently reported that the DNA glycosylase NEIL3 preferentially repairs oxidative lesions in telomere sequences in vitro. Here, we show that loss of NEIL3 causes anaphase DNA bridging because of telomere dysfunction. NEIL3 expression increases during S phase and reaches maximal levels in late S/G2. NEIL3 co-localizes with TRF2 and associates with telomeres during S phase, and this association increases upon oxidative stress. Mec ...[more]