Ontology highlight
ABSTRACT:
SUBMITTER: Tong X
PROVIDER: S-EPMC5606320 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Tong Xin X Zhang Deqiang D Charney Nicholas N Jin Ethan E VanDommelen Kyle K Stamper Kenneth K Gupta Neil N Saldate Johnny J Yin Lei L
Diabetes 20170808 10
Targeted protein degradation through ubiquitination is an important step in the regulation of glucose metabolism. Here, we present evidence that the DDB1-CUL4A ubiquitin E3 ligase functions as a novel metabolic regulator that promotes FOXO1-driven hepatic gluconeogenesis. In vivo, hepatocyte-specific <i>Ddb1</i> deletion leads to impaired hepatic gluconeogenesis in the mouse liver but protects mice from high-fat diet-induced hyperglycemia. Lack of <i>Ddb1</i> downregulates FOXO1 protein expressi ...[more]