Systems biology of oxygen homeostasis.
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ABSTRACT:
SUBMITTER: Samanta D
PROVIDER: S-EPMC5606335 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Systems biology of oxygen homeostasis.
Samanta Debangshu D Prabhakar Nanduri R NR Semenza Gregg L GL
Wiley interdisciplinary reviews. Systems biology and medicine 20170221 4
Metazoan species maintain oxygen homeostasis through the activity of hypoxia-inducible factors, which are transcriptional activators that regulate the expression of hundreds of genes to match O<sub>2</sub> supply and demand. Here, we review the involvement of hypoxia-inducible factors in the molecular physiology and pathophysiology of cellular O<sub>2</sub> sensing, O<sub>2</sub> delivery, O<sub>2</sub> utilization, and systemic O<sub>2</sub> sensing. WIREs Syst Biol Med 2017, 9:e1382. doi: 10.1 ...[more]
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