Unknown

Dataset Information

0

The Investigation of Unexpected Arsenic Compounds Observed in Routine Biological Monitoring Urinary Speciation Analysis.


ABSTRACT: This study investigates the identity of two unexpected arsenic species found separately in a number of urine samples sent to the Health and Safety Executive's Health and Safety Laboratory for arsenic speciation (arsenobetaine, AB; arsenite, As3+; arsenate, As5+; monomethylarsonic acid, MMA5+; and dimethylarsinic acid, DMA5+). Micro liquid chromatography coupled to inductively coupled plasma mass spectrometry (µLC-ICP-MS) and electrospray time of flight tandem mass spectrometry (ESI-QqTOF-MS/MS) were used to identify the two arsenic peaks by comparison to several characterized arsenicals: arsenocholine, AC; trimethyl arsine oxide, TMAO; dimethylarsenoacetate, DMAA; dimethylarsenoethanol, DMAE; thio-dimethylarsinate, thio-DMA; thio-dimethylarsenoacetate, thio-DMAA and thio-dimethylarsenoethanol, thio-DMAE. The results from both the ICP-MS and ESI-QqTOF-MS/MS investigations indicate that the unexpected arsenic species termed peak 1 was thio-DMA. While the unexpected arsenic species termed peak 2 has yet to be identified, this investigation shows that it was not AC, TMAO, DMAA, DMAE, thio-DMA, thio-DMAA or thio-DMAE. This study demonstrates the incidence of unexpected arsenic species in both routine and non-routine urine samples from both workers and hospital patients.

SUBMITTER: Leese E 

PROVIDER: S-EPMC5606668 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

The Investigation of Unexpected Arsenic Compounds Observed in Routine Biological Monitoring Urinary Speciation Analysis.

Leese Elizabeth E   Clench Malcolm M   Morton Jackie J   Gardiner Philip H E PHE   Carolan Vikki A VA  

Toxics 20170520 2


This study investigates the identity of two unexpected arsenic species found separately in a number of urine samples sent to the Health and Safety Executive's Health and Safety Laboratory for arsenic speciation (arsenobetaine, AB; arsenite, As<sup>3+</sup>; arsenate, As<sup>5+</sup>; monomethylarsonic acid, MMA<sup>5+</sup>; and dimethylarsinic acid, DMA<sup>5+</sup>). Micro liquid chromatography coupled to inductively coupled plasma mass spectrometry (µLC-ICP-MS) and electrospray time of flight  ...[more]

Similar Datasets

| S-EPMC2707240 | biostudies-literature
| S-EPMC5849658 | biostudies-literature
| S-EPMC4508369 | biostudies-literature
| S-EPMC4169536 | biostudies-literature
| S-EPMC6257176 | biostudies-literature
| S-EPMC3226497 | biostudies-other
| S-EPMC3670190 | biostudies-literature
| S-EPMC6800155 | biostudies-literature
| S-EPMC8016918 | biostudies-literature
| S-EPMC5615527 | biostudies-literature