Ontology highlight
ABSTRACT:
SUBMITTER: Rapposelli S
PROVIDER: S-EPMC5607332 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Rapposelli Simona S Gambari Laura L Digiacomo Maria M Citi Valentina V Lisignoli Gina G Manferdini Cristina C Calderone Vincenzo V Grassi Francesco F
Scientific reports 20170920 1
Bisphosphonates (BPs) are the first-line treatment of bone loss resulting from various pathological conditions. Due to their high affinity to bone they have been used to develop conjugates with pro-anabolic or anti-catabolic drugs. We recently demontrated that hydrogen sulfide (H<sub>2</sub>S), promotes osteogenesis and inhibits osteoclast differentiation. Here we developed an innovative molecule, named DM-22, obtained from the combination of alendronate (AL) and the H<sub>2</sub>S-releasing moi ...[more]