Ontology highlight
ABSTRACT:
SUBMITTER: Fujiyuki T
PROVIDER: S-EPMC5607339 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Fujiyuki Tomoko T Horie Ryo R Yoneda Misako M Kuraishi Takeshi T Yasui Fumihiko F Kwon Hyun-Jeong HJ Munekata Keisuke K Ikeda Fusako F Hoshi Miho M Kiso Yuri Y Omi Mio M Sato Hiroki H Kida Hiroshi H Hattori Shosaku S Kohara Michinori M Kai Chieko C
Scientific reports 20170920 1
Highly pathogenic avian influenza virus (HPAIV) is a serious threat not only to domestic fowls but also to humans. Vaccines inducing long-lasting immunity against HPAIV are required. In the present study, we generated recombinant measles virus (MV) expressing the hemagglutinin protein of HPAIV without the multibasic site necessary for its pathogenicity in chickens using the backbone of an MV vaccine strain (rMV-Ed-H5HA) or a wild-type MV-derived mutant (rMV-HL-Vko-H5HA). We examined protective e ...[more]