Ontology highlight
ABSTRACT:
SUBMITTER: Mazoure B
PROVIDER: S-EPMC5607347 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Mazoure Bogdan B Nadon Robert R Makarenkov Vladimir V
Scientific reports 20170920 1
Spatial bias continues to be a major challenge in high-throughput screening technologies. Its successful detection and elimination are critical for identifying the most promising drug candidates. Here, we examine experimental small molecule assays from the popular ChemBank database and show that screening data are widely affected by both assay-specific and plate-specific spatial biases. Importantly, the bias affecting screening data can fit an additive or multiplicative model. We show that the u ...[more]