Ontology highlight
ABSTRACT:
SUBMITTER: Kuipers K
PROVIDER: S-EPMC5607416 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Kuipers Kirsten K Jong Wouter S P WSP van der Gaast-de Jongh Christa E CE Houben Diane D van Opzeeland Fred F Simonetti Elles E van Selm Saskia S de Groot Ronald R Koenders Marije I MI Azarian Taj T Pupo Elder E van der Ley Peter P Langereis Jeroen D JD Zomer Aldert A Luirink Joen J de Jonge Marien I MI
Infection and immunity 20170920 10
Serotype-specific protection against <i>Streptococcus pneumoniae</i> is an important limitation of the current polysaccharide-based vaccines. To prevent serotype replacement, reduce transmission, and limit the emergence of new variants, it is essential to induce broad protection and restrict pneumococcal colonization. In this study, we used a prototype vaccine formulation consisting of lipopolysaccharide (LPS)-detoxified outer membrane vesicles (OMVs) from <i>Salmonella enterica</i> serovar Typh ...[more]