Dataset Information

Iterative analysis of cerebrovascular reactivity dynamic response by temporal decomposition.

ABSTRACT:

Objective

To improve quantitative cerebrovascular reactivity (CVR) measurements and CO ₂ arrival times, we present an iterative analysis capable of decomposing different temporal components of the dynamic carbon dioxide- Blood Oxygen-Level Dependent (CO ₂-BOLD) relationship.

Experimental design

Decomposition of the dynamic parameters included a redefinition of the voxel-wise CO ₂ arrival time, and a separation from the vascular response to a stepwise increase in CO ₂ (Delay to signal Plateau - DTP) and a decrease in CO ₂ (Delay to signal Baseline -DTB). Twenty-five (normal) datasets, obtained from BOLD MRI combined with a standardized pseudo-square wave CO ₂ change, were co-registered to generate reference atlases for the aforementioned dynamic processes to score the voxel-by-voxel deviation probability from normal range. This analysis is further illustrated in two subjects with unilateral carotid artery occlusion using these reference atlases.

Principal observations

We have found that our redefined CO ₂ arrival time resulted in the best data fit. Additionally, excluding both dynamic BOLD phases (DTP and DTB) resulted in a static CVR, that is maximal response, defined as CVR calculated only over a normocapnic and hypercapnic calibrated plateau.

Conclusion

Decomposition and novel iterative modeling of different temporal components of the dynamic CO ₂-BOLD relationship improves quantitative CVR measurements.

SUBMITTER: van Niftrik CHB

PROVIDER: S-EPMC5607533 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Iterative analysis of cerebrovascular reactivity dynamic response by temporal decomposition.

van Niftrik Christiaan Hendrik Bas CHB Piccirelli Marco M Bozinov Oliver O Pangalu Athina A Fisher Joseph A JA Valavanis Antonios A Luft Andreas R AR Weller Michael M Regli Luca L Fierstra Jorn J

Brain and behavior 20170726 9

<h4>Objective</h4>To improve quantitative cerebrovascular reactivity (CVR) measurements and CO <sub>2</sub> arrival times, we present an iterative analysis capable of decomposing different temporal components of the dynamic carbon dioxide- Blood Oxygen-Level Dependent (CO <sub>2</sub>-BOLD) relationship.<h4>Experimental design</h4>Decomposition of the dynamic parameters included a redefinition of the voxel-wise CO <sub>2</sub> arrival time, and a separation from the vascular response to a stepwi ...[more]

PMID: 28948064

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Dataset Information

Iterative analysis of cerebrovascular reactivity dynamic response by temporal decomposition.

Objective

Experimental design

Principal observations

Conclusion

Publications

Iterative analysis of cerebrovascular reactivity dynamic response by temporal decomposition.

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