Dataset Information

Apolipoprotein E epsilon 4 (APOE-?4) genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury.

ABSTRACT: INTRODUCTION:The apolipoprotein E (APOE) ?4 allele associates with memory impairment in neurodegenerative diseases. Its association with memory after mild traumatic brain injury (mTBI) is unclear. METHODS:mTBI patients (Glasgow Coma Scale score 13-15, no neurosurgical intervention, extracranial Abbreviated Injury Scale score ?1) aged ?18 years with APOE genotyping results were extracted from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study. Cohorts determined by APOE-?4(+/-) were assessed for associations with 6-month verbal memory, measured by California Verbal Learning Test, Second Edition (CVLT-II) subscales: Immediate Recall Trials 1-5 (IRT), Short-Delay Free Recall (SDFR), Short-Delay Cued Recall (SDCR), Long-Delay Free Recall (LDFR), and Long-Delay Cued Recall (LDCR). Multivariable regression controlled for demographic factors, seizure history, loss of consciousness, posttraumatic amnesia, and acute intracranial pathology on computed tomography (CT). RESULTS:In 114 mTBI patients (APOE-?4(-)=79; APOE-?4(+)=35), ApoE-?4(+) was associated with long-delay verbal memory deficits (LDFR: B = -1.17 points, 95% CI [-2.33, -0.01], p = .049; LDCR: B = -1.58 [-2.63, -0.52], p = .004), and a marginal decrease on SDCR (B = -1.02 [-2.05, 0.00], p = .050). CT pathology was the strongest predictor of decreased verbal memory (IRT: B = -8.49, SDFR: B = -2.50, SDCR: B = -1.85, LDFR: B = -2.61, LDCR: B = -2.60; p < .001). Seizure history was associated with decreased short-term memory (SDFR: B = -1.32, p = .037; SDCR: B = -1.44, p = .038). CONCLUSION:The APOE-?4 allele may confer an increased risk of impairment of 6-month verbal memory for patients suffering mTBI, with implications for heightened surveillance and targeted therapies. Acute intracranial pathology remains the driver of decreased verbal memory performance at 6 months after mTBI.

SUBMITTER: Yue JK

PROVIDER: S-EPMC5607554 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

<i>Apolipoprotein E epsilon 4 (APOE-</i>ε<i>4)</i> genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury.

Yue John K JK Robinson Caitlin K CK Burke John F JF Winkler Ethan A EA Deng Hansen H Cnossen Maryse C MC Lingsma Hester F HF Ferguson Adam R AR McAllister Thomas W TW Rosand Jonathan J Burchard Esteban G EG Sorani Marco D MD Sharma Sourabh S Nielson Jessica L JL Satris Gabriela G GG Talbott Jason F JF Tarapore Phiroz E PE Korley Frederick K FK Wang Kevin K W KKW Yuh Esther L EL Mukherjee Pratik P Diaz-Arrastia Ramon R Valadka Alex B AB Okonkwo David O DO Manley Geoffrey T GT

Brain and behavior 20170809 9

<h4>Introduction</h4>The apolipoprotein E (<i>APOE</i>) ε<i>4</i> allele associates with memory impairment in neurodegenerative diseases. Its association with memory after mild traumatic brain injury (mTBI) is unclear.<h4>Methods</h4>mTBI patients (Glasgow Coma Scale score 13-15, no neurosurgical intervention, extracranial Abbreviated Injury Scale score ≤1) aged ≥18 years with <i>APOE</i> genotyping results were extracted from the Transforming Research and Clinical Knowledge in Traumatic Brain I ...[more]

PMID: 28948085

Similar Datasets

Project description:ImportanceEmerging evidence suggests that long-term exposure to ball heading in soccer, the most popular sport in the world, confers risk for adverse cognitive outcomes. However, the extent to which the apolipoprotein E ?4 (APOE ?4) allele, a common risk factor for neurodegeneration, and ball heading are associated with cognition in soccer players remains unknown.ObjectiveTo determine whether the APOE ?4 allele and 12-month ball heading exposure are associated with verbal memory in a cohort of adult amateur soccer players.Design, settings, and participantsA total of 379 amateur soccer players were enrolled in the longitudinal Einstein Soccer Study from November 11, 2013, through January 23, 2018. Selection criteria included participation in soccer for more than 5 years and for more than 6 months per year. Of the 379 individuals enrolled in the study, 355 were genotyped. Three players were excluded for reporting extreme levels of heading. Generalized estimating equation linear regression models were employed to combine data across visits for a cross-sectional analysis of the data.ExposuresAt each study visit every 3 to 6 months, players completed the HeadCount 12-Month Questionnaire, a validated, computer-based questionnaire to estimate 12-month heading exposure that was categorized as low (quartiles 1 and 2), moderate (quartile 3), and high (quartile 4).Main outcome and measuresVerbal memory was assessed at each study visit using the International Shopping List Delayed Recall task from CogState.ResultsA total of 352 soccer players (256 men and 96 women; median age, 23 years [interquartile range, 21-28 years]) across a total of 1204 visits were analyzed. High levels of heading were associated with worse verbal memory performance (??=?-0.59; 95% CI, -0.93 to -0.25; P?=?.001). There was no main association of APOE ?4 with verbal memory (??=?0.09; 95% CI, -0.24 to 0.42; P?=?.58). However, there was a significant association of APOE ?4 and heading with performance on the ISRL task (?2?=?7.22; P?=?.03 for overall interaction). In APOE ?4-positive players, poorer verbal memory associated with high vs low heading exposure was 4.1-fold greater (APOE ?4 negative, ??=?-0.36; 95% CI, -0.75 to 0.03; APOE ?4 positive, ??=?-1.49; 95% CI, -2.05 to -0.93), and poorer verbal memory associated with high vs moderate heading exposure was 8.5-fold greater (APOE ?4 negative, ??=?-0.13; 95% CI, -0.54 to 0.29; APOE ?4 positive, ??=?-1.11, 95% CI, -1.70 to -0.53) compared with that in APOE ?4-negative players.Conclusions and relevanceThis study suggests that the APOE ?4 allele is a risk factor for worse memory performance associated with higher heading exposure in the prior year, which highlights that assessing genetic risks may ultimately play a role in promoting safer soccer play.

Project description:As few studies have examined the relationship between the apolipoprotein E (APOE) gene and clinical outcomes after military-related traumatic brain injury (TBI), we aimed to determine whether the ?4 allele of the APOE gene influences neuropsychiatric symptoms in veterans with a history of mild-to-moderate TBI. Participants included 133 veterans (TBI?=?79; military controls [MC]?=?54) who underwent APOE genotyping and were divided into ?4+ (TBI?=?18; MC?=?15) and ?4- (TBI?=?61; MC?=?39) groups. All participants underwent evaluation of psychological distress using the Beck Depression Inventory-II, Beck Anxiety Inventory, and PTSD Checklist-Military Version. Two-way analyses of variance were conducted to examine the effect of group (TBI vs. MC) and APOE-?4 status (?4+ vs. ?4-) across symptom measures. There was a significant main effect of group across all symptom measures (TBI > MC; all p values <0.001), no main effect of ?4 genotype (p?=?0.152-0.222), and a significant interaction of group by ?4 genotype across all measures (p?=?0.027-0.047). Specifically, for TBI participants, ?4+ veterans demonstrated significantly higher symptom scores across all measures when compared to ?4- veterans (p?=?0.007-0.015). For MC participants, ?4 status had no effect on the severity of psychiatric symptom scores (p?=?0.585-0.708). Our results demonstrate that, in our well-characterized sample of veterans with history of neurotrauma, possession of the ?4 allele conveys risk for increased symptomatology (i.e., depression, anxiety, and post-traumatic stress disorder), even well outside of the acute phase of injury. Findings suggest a meaningful relationship between APOE genotype and psychiatric distress post-TBI, and they suggest that there is a brain basis for the complex neuropsychiatric presentation often observed in this vulnerable population. Future longitudinal studies are needed in order to further our understanding of how genetic factors influence response to TBI.

Dataset Information

Apolipoprotein E epsilon 4 (APOE-?4) genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury.

Publications

<i>Apolipoprotein E epsilon 4 (APOE-</i>ε<i>4)</i> genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets