Ontology highlight
ABSTRACT:
SUBMITTER: Kushwaha D
PROVIDER: S-EPMC5607872 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Kushwaha Divya D Xu Peng P Kováč Pavol P
RSC advances 20170124 13
Synthetic multivalent glycoclusters that carry carbohydrate antigen epitopes have been recognized as promising candidates for the development of carbohydrate based vaccines. Here we describe a convergent strategy for the synthesis of conjugation-ready multivalent glycoclusters using sugars as versatile core subcarriers. d-Glucose and gentiobiose were converted into poly-alkyne functionalized cores which were then decorated with an azide bearing model ligand d-glucose using click chemistry, to fo ...[more]