Ontology highlight
ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC5607954 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Xu Z Z Nayak D D Yang W W Baskaran G G Ramachandran S S Sarma N N Aloush A A Trulock E E Hachem R R Patterson G A GA Mohanakumar T T
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20150203 7
The pathogenesis of chronic rejection, Bronchiolitis Obliterans Syndrome (BOS) following lung transplantation (LT) is poorly understood. We hypothesized that development of antibodies to HLA (DSA) is associated with dysregulation of microRNA (miRNA) that predisposes BOS. Towards this, miRNA profiling of mononuclear cells from 10 stable LT (DSA(-) BOS(-) ), 10 LT with DSA(+) BOS(-) (DSA group) and 10 LT with DSA(+) BOS(+) (BOS group) were performed. Prediction by mirPath indicated that differenti ...[more]