Ontology highlight
ABSTRACT:
SUBMITTER: Martelotto LG
PROVIDER: S-EPMC5608257 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Martelotto Luciano G LG Baslan Timour T Kendall Jude J Geyer Felipe C FC Burke Kathleen A KA Spraggon Lee L Piscuoglio Salvatore S Chadalavada Kalyani K Nanjangud Gouri G Ng Charlotte K Y CK Moody Pamela P D'Italia Sean S Rodgers Linda L Cox Hilary H da Cruz Paula Arnaud A Stepansky Asya A Schizas Michail M Wen Hannah Y HY King Tari A TA Norton Larry L Weigelt Britta B Hicks James B JB Reis-Filho Jorge S JS
Nature medicine 20170206 3
A substantial proportion of tumors consist of genotypically distinct subpopulations of cancer cells. This intratumor genetic heterogeneity poses a substantial challenge for the implementation of precision medicine. Single-cell genomics constitutes a powerful approach to resolve complex mixtures of cancer cells by tracing cell lineages and discovering cryptic genetic variations that would otherwise be obscured in tumor bulk analyses. Because of the chemical alterations that result from formalin f ...[more]