Ontology highlight
ABSTRACT:
SUBMITTER: Yasur-Landau D
PROVIDER: S-EPMC5608428 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Yasur-Landau Daniel D Jaffe Charles L CL Doron-Faigenboim Adi A David Lior L Baneth Gad G
PLoS neglected tropical diseases 20170911 9
Resistance to allopurinol in zoonotic canine leishmaniasis has been recently shown to be associated with disease relapse in naturally-infected dogs. However, information regarding the formation of resistance and its dynamics is lacking. This study describes the successful in-vitro induction of allopurinol resistance in Leishmania infantum cultured under increasing drug pressure. Allopurinol susceptibility and growth rate of induced parasites were monitored over 23 weeks and parasite clones were ...[more]