Ontology highlight
ABSTRACT:
SUBMITTER: Chang CW
PROVIDER: S-EPMC5608508 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Chang Chia-Wei CW Wilkerson Julia R JR Hale Carly F CF Gibson Jay R JR Huber Kimberly M KM
eLife 20170913
Experience and activity refine cortical circuits through synapse elimination, but little is known about the activity patterns and downstream molecular mechanisms that mediate this process. We used optogenetics to drive individual mouse CA1 hippocampal neurons to fire in theta frequency bursts to understand how cell autonomous, postsynaptic activity leads to synapse elimination. Brief (1 hr) periods of postsynaptic bursting selectively depressed AMPA receptor (R) synaptic transmission, or silence ...[more]