Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC5608510 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Liu Song S Kumari Sangeeta S Hu Qiang Q Senapati Dhirodatta D Venkadakrishnan Varadha Balaji VB Wang Dan D DePriest Adam D AD Schlanger Simon E SE Ben-Salem Salma S Valenzuela Malyn May MM Willard Belinda B Mudambi Shaila S Swetzig Wendy M WM Das Gokul M GM Shourideh Mojgan M Koochekpour Shahriah S Falzarano Sara Moscovita SM Magi-Galluzzi Cristina C Yadav Neelu N Chen Xiwei X Lao Changshi C Wang Jianmin J Billaud Jean-Noel JN Heemers Hannelore V HV
eLife 20170818
Standard treatment for metastatic prostate cancer (CaP) prevents ligand-activation of androgen receptor (AR). Despite initial remission, CaP progresses while relying on AR. AR transcriptional output controls CaP behavior and is an alternative therapeutic target, but its molecular regulation is poorly understood. Here, we show that action of activated AR partitions into fractions that are controlled preferentially by different coregulators. In a 452-AR-target gene panel, each of 18 clinically rel ...[more]