Dataset Information

Laryngeal paracoccidioidomycosis presenting as solitary true vocal fold disease.

ABSTRACT: Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis or P. lutzii. It is a neglected tropical infectious disease that poses a major public health burden in endemic areas of Latin America. Mucosae of the upper digestive and respiratory tracts are commonly involved and many patients have disease at multiple mucosal sites, with or without lung involvement. Mucosal PCM presenting as solitary true vocal fold disease is relatively rare. We present the case of a 67-year-old Brazilian forest guard who presented with a 6-month history of hoarseness and globus pharyngeus due to a solitary left true vocal fold infiltration and vegetation diagnosed as PCM. Silent pulmonary disease was also present. A laryngoscopy video is offered as supplemental material to this report. He completely remitted after surgical removal and amphotericin B deoxycholate treatment.

SUBMITTER: Eyer-Silva WA

PROVIDER: S-EPMC5608563 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Laryngeal paracoccidioidomycosis presenting as solitary true vocal fold disease.

Eyer-Silva Walter de Araujo WA Santana Annelise Callmann AC Silva Guilherme Almeida Rosa da GARD Azevedo Marcelo Costa Velho Mendes de MCVM Barreto Juliana Li Ting Matos Sun JLTMS Neumann Marina Apolloni MA Castro Izana Junqueira de IJ Basílio-de-Oliveira Rodrigo Panno RP Araujo Luciana Ferreira de LF Ré Nathane Zanineli NZ Oliveira Felipe Marques de FM Simas Caio José de Araujo CJA Sarvat Marcos André de MA Ferry Fernando Raphael de Almeida FRA

IDCases 20170914

Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by <i>Paracoccidioides brasiliensis</i> or <i>P. lutzii</i>. It is a neglected tropical infectious disease that poses a major public health burden in endemic areas of Latin America. Mucosae of the upper digestive and respiratory tracts are commonly involved and many patients have disease at multiple mucosal sites, with or without lung involvement. Mucosal PCM presenting as solitary true vocal fold disease is relatively rare. ...[more]

PMID: 28966914

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Project description:MotivationHuman voice is generated in the larynx by the two oscillating vocal folds. Owing to the limited space and accessibility of the larynx, endoscopic investigation of the actual phonatory process in detail is challenging. Hence the biomechanics of the human phonatory process are still not yet fully understood. Therefore, we adapt a mathematical model of the vocal folds towards vocal fold oscillations to quantify gender and age related differences expressed by computed biomechanical model parameters.MethodsThe vocal fold dynamics are visualized by laryngeal high-speed videoendoscopy (4000 fps). A total of 33 healthy young subjects (16 females, 17 males) and 11 elderly subjects (5 females, 6 males) were recorded. A numerical two-mass model is adapted to the recorded vocal fold oscillations by varying model masses, stiffness and subglottal pressure. For adapting the model towards the recorded vocal fold dynamics, three different optimization algorithms (Nelder-Mead, Particle Swarm Optimization and Simulated Bee Colony) in combination with three cost functions were considered for applicability. Gender differences and age-related kinematic differences reflected by the model parameters were analyzed.Results and conclusionThe biomechanical model in combination with numerical optimization techniques allowed phonatory behavior to be simulated and laryngeal parameters involved to be quantified. All three optimization algorithms showed promising results. However, only one cost function seems to be suitable for this optimization task. The gained model parameters reflect the phonatory biomechanics for men and women well and show quantitative age- and gender-specific differences. The model parameters for younger females and males showed lower subglottal pressures, lower stiffness and higher masses than the corresponding elderly groups. Females exhibited higher subglottal pressures, smaller oscillation masses and larger stiffness than the corresponding similar aged male groups. Optimizing numerical models towards vocal fold oscillations is useful to identify underlying laryngeal components controlling the phonatory process.

Dataset Information

Laryngeal paracoccidioidomycosis presenting as solitary true vocal fold disease.

Publications

Laryngeal paracoccidioidomycosis presenting as solitary true vocal fold disease.

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