Ontology highlight
ABSTRACT:
SUBMITTER: Patel A
PROVIDER: S-EPMC5608701 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Patel Ami A DiGiandomenico Antonio A Keller Ashley E AE Smith Trevor R F TRF Park Daniel H DH Ramos Stephanie S Schultheis Katherine K Elliott Sarah T C STC Mendoza Janess J Broderick Kate E KE Wise Megan C MC Yan Jian J Jiang Jingjing J Flingai Seleeke S Khan Amir S AS Muthumani Kar K Humeau Laurent L Cheng Lily I LI Wachter-Rosati Leslie L Stover C Kendall CK Sardesai Niranjan Y NY Weiner David B DB
Nature communications 20170921 1
The impact of broad-spectrum antibiotics on antimicrobial resistance and disruption of the beneficial microbiome compels the urgent investigation of bacteria-specific approaches such as antibody-based strategies. Among these, DNA-delivered monoclonal antibodies (DMAbs), produced by muscle cells in vivo, potentially allow the prevention or treatment of bacterial infections circumventing some of the hurdles of protein IgG delivery. Here, we optimize DNA-delivered monoclonal antibodies consisting o ...[more]