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Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins.

ABSTRACT: Some of the Chronic Obstructive Pulmonary Disease (COPD) patients engaged in exercise-based muscle rehabilitation programs are unresponsive. To unravel the respective role of chronic hypoxia and pulmonary inflammation on soleus muscle hypertrophic capacities, we challenged male Wistar rats to repeated lipopolysaccharide instillations, associated or not with a chronic hypoxia exposure. Muscle hypertrophy was initiated by bilateral ablation of soleus agonists 1 week before sacrifice. To understand the role played by the histone acetylation, we also treated our animals with an inhibitor of bromodomains and extra terminal proteins (I-BET) during the week after surgery. Pulmonary inflammation totally inhibited this hypertrophy response under both normoxic and hypoxic conditions (26% lower than control surgery, p?

SUBMITTER: Chabert C

PROVIDER: S-EPMC5608715 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins.

Chabert Clovis C Khochbin Saadi S Rousseaux Sophie S Furze Rebecca R Smithers Nicholas N Prinjha Rab R Schlattner Uwe U Pison Christophe C Dubouchaud Hervé H

Scientific reports 20170921 1

Some of the Chronic Obstructive Pulmonary Disease (COPD) patients engaged in exercise-based muscle rehabilitation programs are unresponsive. To unravel the respective role of chronic hypoxia and pulmonary inflammation on soleus muscle hypertrophic capacities, we challenged male Wistar rats to repeated lipopolysaccharide instillations, associated or not with a chronic hypoxia exposure. Muscle hypertrophy was initiated by bilateral ablation of soleus agonists 1 week before sacrifice. To understand ...[more]

PMID: 28935884

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Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation.

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| S-EPMC7063807 | biostudies-literature

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins.

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| S-EPMC8232216 | biostudies-literature

The suppression of bromodomain and extra-terminal domain inhibits vascular inflammation by blocking NF-κB and MAPK activation.

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| S-EPMC5341496 | biostudies-literature

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