Expression of Mullerian inhibiting substance type II receptor and antiproliferative effects of MIS on human cervical cancer.

ABSTRACT: This study aimed to analyze expression of Müllerian inhibiting substance type II receptor (MISRII) protein and mRNA in cervical neoplasia, to demonstrate the growth inhibition of cervical cancer cells by administration of highly purified recombinant human Müllerian inhibiting substance (MIS) and, furthermore, to evaluate the clinical significance of MIS as a biological modifier for MIS receptor expressing tumors. Reverse transcriptase polymerase chain reaction (RT-PCR) was used for MISRII mRNA expression, and in situ hybridization and immunohistochemistry were used to observe expression, location of MISRII mRNA and protein, respectively. To demonstrate the effect of MIS on the viability of cervi

SUBMITTER: Song JY 

PROVIDER: S-EPMC5609185 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature