Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer.
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ABSTRACT:
SUBMITTER: Dreijerink KMA
PROVIDER: S-EPMC5609449 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer.
Dreijerink Koen M A KMA Groner Anna C AC Vos Erica S M ESM Font-Tello Alba A Gu Lei L Chi David D Reyes Jaime J Cook Jennifer J Lim Elgene E Lin Charles Y CY de Laat Wouter W Rao Prakash K PK Long Henry W HW Brown Myles M
Cell reports 20170301 10
While the multiple endocrine neoplasia type 1 (MEN1) gene functions as a tumor suppressor in a variety of cancer types, we explored its oncogenic role in breast tumorigenesis. The MEN1 gene product menin is involved in H3K4 trimethylation and co-activates transcription. We integrated ChIP-seq and RNA-seq data to identify menin target genes. Our analysis revealed that menin-dependent target gene promoters display looping to distal enhancers that are bound by menin, FOXA1 and GATA3. In this fashio ...[more]
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