Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC5609925 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Chen Xue X Liu Hongyang H Wang Zhirong Z Wang Shuo S Zhang Ting T Hu Meili M Qiao Liang L Xu Xuemei X
Oncotarget 20170718 38
The neutralizing antibodies elicited by human papillomavirus (HPV) major capsid protein L1 virus-like particle (VLP)-based vaccines are largely type-specific. An HPV vaccine inducing cross-neutralizing antibodies broadly will be cost-effective and of great value. To this end, we constructed HPV16L1-58L2 chimeric VLP (cVLP) by displaying HPV58 L2 aa.16-37 on the DE surface region of HPV16 L1. We found that vaccination with the HPV16L1-58L2 cVLP formulated with alum plus monophosphoryl lipid A (Al ...[more]