Ontology highlight
ABSTRACT:
SUBMITTER: De Wolf K
PROVIDER: S-EPMC5610443 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
De Wolf Katrien K Rottey Sylvie S Vermaelen Karim K Decaestecker Karel K Sundahl Nora N De Lobel Lizzy L Goetghebeur Els E De Meerleer Gert G Lumen Nicolaas N Fonteyne Valérie V De Maeseneer Daan D Ost Piet P
Radiation oncology (London, England) 20170922 1
<h4>Background</h4>The primary objective was to determine maximum tolerated radiation dose in patients with metastatic renal cell carcinoma on pazopanib treatment.<h4>Methods</h4>Treatment-naïve patients received pazopanib according to standard of care. Stereotactic body radiotherapy (SBRT) was delivered concurrently to the largest metastatic lesion at day 8, 10 and 12. SBRT doses were escalated in 3 dose levels (24 Gy/3, 30 Gy/3 and 36 Gy/3). Dose level was assigned using Time-to-Event Continua ...[more]