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Signaling noncomprehension of language: a comparison of fragile X syndrome and Down syndrome.

ABSTRACT: Signaling noncomprehension of the spoken messages of others was examined for youth with fragile X or Down syndrome in comparison with each other and nonverbal MA-matched typically developing children. A direction-following task was used in which some of the directions were inadequate. Both syndrome groups signaled noncomprehension less often than did the typically developing children. The ability to signal noncomprehension appropriately was related to a measure of receptive vocabulary and syntax. Preliminary analyses indicated that males with fragile X syndrome signaled noncomprehension less often than did their female peers, even after controlling for differences in nonverbal MA.

SUBMITTER: Abbeduto L

PROVIDER: S-EPMC5610960 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature

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Signaling noncomprehension of language: a comparison of fragile X syndrome and Down syndrome.

Abbeduto Leonard L Murphy Melissa M MM Kover Sara T ST Giles Nancy D ND Karadottir Selma S Amman Adrienne A Bruno Loredana L Kim Jee-Seon JS Schroeder Susen S Anderson Julie A JA Nollin Kathryn A KA

American journal of mental retardation : AJMR 20080501 3

Signaling noncomprehension of the spoken messages of others was examined for youth with fragile X or Down syndrome in comparison with each other and nonverbal MA-matched typically developing children. A direction-following task was used in which some of the directions were inadequate. Both syndrome groups signaled noncomprehension less often than did the typically developing children. The ability to signal noncomprehension appropriately was related to a measure of receptive vocabulary and syntax ...[more]

PMID: 18407723

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Expressive language profiles of verbally expressive adolescents and young adults with Down syndrome or fragile X syndrome.

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Project description:The goal of this study was to define molecular overlap between Down syndrome and Fragile X syndrome using human pluripotent stem cells (hPSCs) and in vitro derived glutamatergic neurons.

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