Ontology highlight
ABSTRACT:
SUBMITTER: Su LY
PROVIDER: S-EPMC5612517 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Su Ling-Yan LY Luo Rongcan R Liu Qianjin Q Su Jing-Ran JR Yang Lu-Xiu LX Ding Yu-Qiang YQ Xu Lin L Yao Yong-Gang YG
Autophagy 20170719 9
The molecular basis of chronic morphine exposure remains unknown. In this study, we hypothesized that macroautophagy/autophagy of dopaminergic neurons would mediate the alterations of neuronal dendritic morphology and behavioral responses induced by morphine. Chronic morphine exposure caused Atg5 (autophagy-related 5)- and Atg7 (autophagy-related 7)-dependent and dopaminergic neuron-specific autophagy resulting in decreased neuron dendritic spines and the onset of addictive behaviors. In culture ...[more]