MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer.
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ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC5612679 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer.
Wang Wanqin W Zhao Jun J Wen Xiaoxia X Lin Curtis Chun-Jen CC Li Junjie J Huang Qian Q Yu Yongqiang Y Lin Shiaw-Yih SY Li Chun C
Contrast media & molecular imaging 20170514
AXL receptor tyrosine kinase is overexpressed in a number of solid tumor types including triple-negative breast cancer (TNBC). AXL is considered an important regulator of epithelial-to-mesenchymal transition (EMT) and a potential therapeutic target for TNBC. In this work, we used microPET/CT with <sup>64</sup>Cu-labeled anti-human AXL antibody (<sup>64</sup>Cu-anti-hAXL) to noninvasively interrogate the degradation of AXL in vivo in response to 17-allylamino-17-demethoxygeldanamycin (17-AAG), a ...[more]
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