Ontology highlight
ABSTRACT:
SUBMITTER: Bihorel S
PROVIDER: S-EPMC5613202 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
CPT: pharmacometrics & systems pharmacology 20170922 9
The objectives of this study were to characterize the pharmacokinetics (PK) of LY2510924, a potent peptide antagonist of the CXCR4 receptor, after subcutaneous administration in patients with advanced cancer forms and quantify LY2510924 stimulatory effects on the mobilization of cells bearing the cluster of differentiation 34 (CD34) as an indirect reflection of the chemokine C-X-C motif ligand 12/CXCR4 axis inhibition. LY2510924 PK were best characterized by a two-compartment model with first-or ...[more]