Ontology highlight
ABSTRACT:
SUBMITTER: Yu H
PROVIDER: S-EPMC5613209 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Yu Hai H Zheng Jian J Liu Xiaobai X Xue Yixue Y Shen Shuyuan S Zhao Lini L Li Zhen Z Liu Yunhui Y
Frontiers in molecular neuroscience 20170921
Glioblastoma (GBM) is the most aggressive primary intracranial tumor of adults and confers a poor prognosis due to high vascularization. Hence anti-angiogenic therapy has become a promising strategy for GBM treatment. In this study, the transcription factor nuclear factor of activated T-cells 5 (NFAT5) was significantly elevated in glioma samples and GBM cell lines, and positively correlated with glioma WHO grades. Knockdown of <i>NFAT5</i> inhibited GBM cell-driven angiogenesis. Furthermore, lo ...[more]