Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka S
PROVIDER: S-EPMC5613769 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Tanaka Shoko S Kobayashi Wakako W Haraguchi Misako M Ishihata Kiyohide K Nakamura Norifumi N Ozawa Masayuki M
Biochemistry and biophysics reports 20160820
The epithelial-mesenchymal transition (EMT) is a fundamental characteristic of carcinoma cells. EMT is generally associated with a change in cellular morphology from cobblestone to spindle shape, reduced expression of epithelial markers such as E-cadherin, and enhanced expression of mesenchymal markers such as N-cadherin. This EMT-associated reciprocal expression of E-cadherin and N-cadherin has been called the "cadherin switch". Downregulation of E-cadherin enables cells to dissociate from colo ...[more]