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Antigenic variation by Borrelia hermsii occurs through recombination between extragenic repetitive elements on linear plasmids.


ABSTRACT: The relapsing fever agent Borrelia hermsii undergoes multiphasic antigenic variation through gene conversion of a unique expression site on a linear plasmid by an archived variable antigen gene. To further characterize this mechanism we assessed the repertoire and organization of archived variable antigen genes by sequencing approximately 85% of plasmids bearing these genes. Most archived genes shared with the expressed gene a

SUBMITTER: Dai Q 

PROVIDER: S-EPMC5614446 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature

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Antigenic variation by Borrelia hermsii occurs through recombination between extragenic repetitive elements on linear plasmids.

Dai Qiyuan Q   Restrepo Blanca I BI   Porcella Stephen F SF   Raffel Sandra J SJ   Schwan Tom G TG   Barbour Alan G AG  

Molecular microbiology 20060601 6


The relapsing fever agent Borrelia hermsii undergoes multiphasic antigenic variation through gene conversion of a unique expression site on a linear plasmid by an archived variable antigen gene. To further characterize this mechanism we assessed the repertoire and organization of archived variable antigen genes by sequencing approximately 85% of plasmids bearing these genes. Most archived genes shared with the expressed gene a <or= 62 nucleotide (nt) region, the upstream homology sequence (UHS),  ...[more]

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