MAb Das-1 is specific for high-risk and malignant intraductal papillary mucinous neoplasm (IPMN).

ABSTRACT:

Objective

Intraductal papillary mucinous neoplasm (IPMN) consists of four epithelial subtypes that correlate with histological grades and risks for malignant transformation. mAb Das-1 is a monoclonal antibody against a colonic epithelial phenotype that is reactive to premalignant conditions of the upper GI tract. We sought to assess the ability of mAb Das-1 to identify IPMN with high risk of malignant transformation.

Design

mAb Das-1 reactivity was evaluated in 94 patients with IPMNs by immunohistochemistry. Lesional fluid from 38 separate patients with IPMN (n=27), low-grade non-mucinous cystic neoplasms (n=7) and pseudocysts (n=4) was analysed by ELISA and western blot.

Results

Immunohistochemistry-Normal pancreatic ducts were non-reactive and low-grade gastric-type

SUBMITTER: Das KK 

PROVIDER: S-EPMC5614500 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature