Ontology highlight
ABSTRACT:
SUBMITTER: Olson OC
PROVIDER: S-EPMC5614506 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Olson Oakley C OC Kim Hyunjung H Quail Daniela F DF Foley Emily A EA Joyce Johanna A JA
Cell reports 20170401 1
Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest and subsequent cell death. Despite the broad utility of these drugs in breast cancer and other tumor types, clinical response remains variable. Tumor-associated macrophages (TAMs) suppress the duration of Taxol-induced mitotic arrest in breast cancer cells and promote earlier mitotic slippage. This correlates with a decrease in the phosphorylated form of histone H2AX (γH2AX), decreased p53 act ...[more]