Ontology highlight
ABSTRACT:
SUBMITTER: Jang JP
PROVIDER: S-EPMC5614539 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Jang Jun-Pil JP Jung Hye Jin HJ Han Jang Mi JM Jung Narae N Kim Yonghyo Y Kwon Ho Jeong HJ Ko Sung-Kyun SK Soung Nak-Kyun NK Jang Jae-Hyuk JH Ahn Jong Seog JS
PloS one 20170926 9
In the course of searching for angiogenesis inhibitors from microorganisms, two cyclic peptides, PF1171A (1) and PF1171C (2) were isolated from the soil fungus Penicillium sp. FN070315. In the present study, we investigated the antiangiogenic efficacy and associated mechanisms of 1 and 2 in vitro using human umbilical vein endothelial cells (HUVECs). Compounds 1 and 2 inhibited the proliferation of HUVECs at concentrations not exhibiting cytotoxicity. Moreover, 1 and 2 significantly suppressed v ...[more]