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Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities.


ABSTRACT: In the course of searching for angiogenesis inhibitors from microorganisms, two cyclic peptides, PF1171A (1) and PF1171C (2) were isolated from the soil fungus Penicillium sp. FN070315. In the present study, we investigated the antiangiogenic efficacy and associated mechanisms of 1 and 2 in vitro using human umbilical vein endothelial cells (HUVECs). Compounds 1 and 2 inhibited the proliferation of HUVECs at concentrations not exhibiting cytotoxicity. Moreover, 1 and 2 significantly suppressed vascular endothelial growth factor (VEGF)-induced migration, invasion, proliferation and tube formation of HUVECs as well as neovascularization of the chorioallantoic membrane in developing chick embryos. We also identified an association between the antiangiogenic activity of 1 and 2 and the downregulation of both the phosphorylation of VEGF receptor 2 and the expression of hypoxia inducible factor-1? at the protein level. Taken together, these results further suggest that compounds 1 and 2 will be promising angiogenesis inhibitors.

SUBMITTER: Jang JP 

PROVIDER: S-EPMC5614539 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities.

Jang Jun-Pil JP   Jung Hye Jin HJ   Han Jang Mi JM   Jung Narae N   Kim Yonghyo Y   Kwon Ho Jeong HJ   Ko Sung-Kyun SK   Soung Nak-Kyun NK   Jang Jae-Hyuk JH   Ahn Jong Seog JS  

PloS one 20170926 9


In the course of searching for angiogenesis inhibitors from microorganisms, two cyclic peptides, PF1171A (1) and PF1171C (2) were isolated from the soil fungus Penicillium sp. FN070315. In the present study, we investigated the antiangiogenic efficacy and associated mechanisms of 1 and 2 in vitro using human umbilical vein endothelial cells (HUVECs). Compounds 1 and 2 inhibited the proliferation of HUVECs at concentrations not exhibiting cytotoxicity. Moreover, 1 and 2 significantly suppressed v  ...[more]

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